Nature Communications (Oct 2021)

Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

  • Jia Wei,
  • Philippa C. Matthews,
  • Nicole Stoesser,
  • Thomas Maddox,
  • Luke Lorenzi,
  • Ruth Studley,
  • John I. Bell,
  • John N. Newton,
  • Jeremy Farrar,
  • Ian Diamond,
  • Emma Rourke,
  • Alison Howarth,
  • Brian D. Marsden,
  • Sarah Hoosdally,
  • E. Yvonne Jones,
  • David I. Stuart,
  • Derrick W. Crook,
  • Tim E. A. Peto,
  • Koen B. Pouwels,
  • A. Sarah Walker,
  • David W. Eyre,
  • the COVID-19 Infection Survey team

Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12


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Most people who are infected with SARS-CoV-2 seroconvert within a few weeks, but the determinants and duration of the antibody response are not known. Here, the authors characterise these features of the immune response using data from a large representative community sample of the UK population.