Twisted Fiber Optic SPR Sensor for GDF11 Concentration Detection
Yong Wei,
Ze Ran,
Rui Wang,
Zhuo Ren,
Chun-Lan Liu,
Chun-Biao Liu,
Chen Shi,
Chen Wang,
Yong-Hui Zhang
Affiliations
Yong Wei
College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China
Ze Ran
College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China
Rui Wang
College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China
Zhuo Ren
College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China
Chun-Lan Liu
College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China
Chun-Biao Liu
College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China
Chen Shi
College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China
Chen Wang
Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College, Chongqing 404120, China
Yong-Hui Zhang
Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College, Chongqing 404120, China
There are few methods and insufficient accuracy for growth differentiation factor 11 (GDF11) concentration detection. In this paper, we designed a twisted fiber cladding surface plasmon resonance (SPR) sensor, which can achieve a high precision detection of GDF11 concentration. The new structure of the fiber cladding SPR sensor was realized by coupling the light in the fiber core to the cladding through fiber thermal fusion twisting micromachining technology; a series of functionalized modifications were made to the sensor surface to obtain a fiber sensor capable of GDF11 specific recognition. The experimental results showed when GDF11 antigen concentration was 1 pg/mL–10 ng/mL, the sensor had a detection sensitivity of 2.518 nm/lgC, a detection limit of 0.34 pg/mL, and a good log-linear relationship. The sensor is expected to play a role in the rapid and accurate concentration detection of pathological study for growth differentiation factors.
