Cancer Management and Research (Apr 2024)
Lymphoepithelioma-Like Intrahepatic Cholangiocarcinoma Associated with Epstein–Barr Virus and Hepatitis Virus: Case Report and a Literature Review
Abstract
Hao-Kun Qin,1 Dong-Dong Xue,2 Huai-Bin Guo2 1Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of General Surgery, Hebei General Hospital, Shijiazhuang, People’s Republic of ChinaCorrespondence: Huai-Bin Guo, Email [email protected]: Lymphoepithelioma-like carcinoma of the liver is a rare primary malignancy of the liver. The identification of lymphoepithelioma-like cholangiocarcinoma is very limited as there are currently very few reports of such cases. Although previous studies have reported the lymphoepithelioma-like cholangiocarcinoma pathologic features, few studies have revealed the clinic features, imaging characteristics, and clinical course and outcomes. This study was analyzed from multiple aspects such as contrast-enhanced ultrasound, magnetic resonance imaging, and pathological characteristics, aiming to improve the comprehensive understanding of this rare subtype of disease.Case Presentation: A 43-year-old female with a history of hepatitis B for over 20 years presented with a lesion found in the right lobe of her liver. After discussion by a multidisciplinary team (MDT), malignant tumors cannot be excluded based on contrast-enhanced ultrasound and MRI. Thus, we decided to perform surgery for the patient. Postoperative pathology confirmed lymphoepithelioma-like intrahepatic cholangiocarcinoma. After 3 months of follow-up, the patient was still alive and no recurrence was observed.Conclusion: The purpose of this article is to describe a rare case of lymphoepithelioma-like intrahepatic cholangiocarcinoma and analyze its contrast-enhanced ultrasound and contrast-enhanced MRI features, which will be helpful for physicians in diagnosing this disease. From the perspective of CEUS, the wedge-shaped highly enhanced area around the lesion in the arterial phase appears to be inflammatory but looks malignant based on the extremely fast washout. The lesion showed a low signal on T1WI, a high signal on T2WI and DWI, and an abnormal perfusion shadow can be seen behind the lesion. In particular, this subtype of cholangiocarcinoma has a good prognosis, the clinician should improve the recognition of the disease to strive for early diagnosis and therapy.Keywords: lymphoepithelioma-like carcinoma, intrahepatic cholangiocarcinoma, contrast-enhanced ultrasound, magnetic resonance imaging, epstein-barr virus
