Nature Communications (May 2021)

FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer

  • Yun Huang,
  • Hai-Liang Zhang,
  • Zhi-Ling Li,
  • Tian Du,
  • Yu-Hong Chen,
  • Yan Wang,
  • Huan-He Ni,
  • Kai-Ming Zhang,
  • Jia Mai,
  • Bing-Xin Hu,
  • Jun-Hao Huang,
  • Li-Huan Zhou,
  • Dong Yang,
  • Xiao-Dan Peng,
  • Gong-Kan Feng,
  • Jun Tang,
  • Xiao-Feng Zhu,
  • Rong Deng

DOI
https://doi.org/10.1038/s41467-021-22618-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

B7H3 is a transmembrane B7 family checkpoint molecule present on many cancer cells. Here the authors show that FUT8 mediates fucosylation of B7H3 to limit the immune response to triple-negative breast cancer as a potentially targeted mechanism of non-responsiveness to current checkpoint therapies.