Alkaloids with Their Protective Effects Against A<i>β</i><sub>25-35</sub>-Induced PC-12 Cell Injury from the Tubers of <i>Pinellia pedatisecta</i> Schott
Xu Chen,
Yangang Cao,
Kaili Ye,
Yanling Liu,
Fangge Chi,
Ying Niu,
Di Lu,
Bingxian Zhao,
Lan Chen,
Xiaoke Zheng,
Weisheng Feng
Affiliations
Xu Chen
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Yangang Cao
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Kaili Ye
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Yanling Liu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Fangge Chi
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Ying Niu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Di Lu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Bingxian Zhao
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Lan Chen
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Xiaoke Zheng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Weisheng Feng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] and one new natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)-3, 6, and 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP).
