The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis

Abstract

Highlights Biomarkers of oxidative stress are related to the pathogenesis of preeclampsia and might be indicative of evolving preeclampsia and utilized for timely diagnosis and management of preeclampsia. Systematic review and meta-analysis were conducted to evaluate the diagnostic accuracy of oxidative stress markers based on their diagnostic sensitivities and specificities. Clinically relevant positive predictive values (PPVs) and negative predictive values (NPVs) were determined for each biomarker. IMA, UA, and MDA were associated with 3.38, 3.05, and 2.37 odds ratios for preeclampsia onset. IMA exhibited the most promising diagnostic potential with an average PPV of 0.852 and NPV of 0.811, respectively. Minor heterogeneity was reported for these biomarkers (Higgins’ I 2 = 0–15.879%). These oxidative stress markers should be further explored in larger cohorts for preeclampsia diagnosis.

Keywords

• Preeclampsia
• Oxidative stress
• Heavy metals
• Biomarkers
• MDA
• IMA