Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
Sandra Lucía Teniente,
Adriana Carolina Flores-Gallegos,
Sandra Cecilia Esparza-González,
Lizeth Guadalupe Campos-Múzquiz,
Sendar Daniel Nery-Flores,
Raul Rodríguez-Herrera
Affiliations
Sandra Lucía Teniente
Food Research Department, School of Chemistry, Universidad Autónoma de Coahuila, Blvd. Venustiano Carranza and José Cárdenas, República Oriente, Saltillo 25280, Coahuila, Mexico
Adriana Carolina Flores-Gallegos
Food Research Department, School of Chemistry, Universidad Autónoma de Coahuila, Blvd. Venustiano Carranza and José Cárdenas, República Oriente, Saltillo 25280, Coahuila, Mexico
Sandra Cecilia Esparza-González
School of Dentistry, Universidad Autónoma de Coahuila, Dra. Cuquita Cepeda de Dávila Ave, Adolfo López Mateos, Saltillo 25125, Coahuila, Mexico
Lizeth Guadalupe Campos-Múzquiz
Food Research Department, School of Chemistry, Universidad Autónoma de Coahuila, Blvd. Venustiano Carranza and José Cárdenas, República Oriente, Saltillo 25280, Coahuila, Mexico
Sendar Daniel Nery-Flores
Food Research Department, School of Chemistry, Universidad Autónoma de Coahuila, Blvd. Venustiano Carranza and José Cárdenas, República Oriente, Saltillo 25280, Coahuila, Mexico
Raul Rodríguez-Herrera
Food Research Department, School of Chemistry, Universidad Autónoma de Coahuila, Blvd. Venustiano Carranza and José Cárdenas, República Oriente, Saltillo 25280, Coahuila, Mexico
Polyphenols are a broad group of bioactive phytochemicals with powerful antioxidant, anti-inflammatory, immunomodulatory, and antiviral activities. Numerous studies have demonstrated that polyphenol extracts obtained from natural sources can be used for the prevention and treatment of cancer. Pomegranate peel extract is an excellent source of polyphenols, such as punicalagin, punicalin, ellagic acid, and caffeic acid, among others. These phenolic compounds have antineoplastic activity in in vitro models of cervical cancer through the regulation of cellular redox balance, induction of apoptosis, cell cycle arrest, and modulation of different signaling pathways. The current review summarizes recent data from scientific reports that address the anticancer activity of the predominant polyphenol compounds present in PPE and their different mechanisms of action in cervical cancer models.
