Evaluation of the Antidiabetic and Antihyperlipidemic Activity of <i>Spondias purpurea</i> Seeds in a Diabetic Zebrafish Model
Alethia Muñiz-Ramirez,
Abraham Heriberto Garcia-Campoy,
Rosa Martha Pérez Gutiérrez,
Efrén Venancio Garcia Báez,
José María Mota Flores
Affiliations
Alethia Muñiz-Ramirez
CONACYT-IPICYT/CIIDZA, Camino a la Presa de San José 2055, Colonia, Lomas 4 Sección, San Luis Potosí CP 78216, Mexico
Abraham Heriberto Garcia-Campoy
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas, Instituto Politécnico Nacional, Ciudad de México CP 07708, Mexico
Rosa Martha Pérez Gutiérrez
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas, Instituto Politécnico Nacional, Ciudad de México CP 07708, Mexico
Efrén Venancio Garcia Báez
Laboratorio de Química Supramolecular y Nanociencias, Instituto Politécnico Nacional, Acueducto S/N, Barrio la laguna Ticomán, Ciudad de México CP 07340, Mexico
José María Mota Flores
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas, Instituto Politécnico Nacional, Ciudad de México CP 07708, Mexico
Diabetes mellitus (DM) is a serious chronic degenerative disease characterized by high levels of glucose in the blood. It is associated with an absolute or relative deficiency in the production and/or action of insulin. Some of the complications associated with DM are heart disease, retinopathy, kidney disease, and neuropathy; therefore, new natural alternatives are being sought to control the disease. In this work, we evaluate the antidiabetic effect of Spondias purpurea seed methanol extract (CSM) in vitro and in a glucose-induced diabetic zebrafish model. CSM is capable of lowering blood glucose and cholesterol levels, as well as forming advanced glycation end-products, while not presenting toxic effects at the concentrations evaluated. These data show that CSM has a promising antidiabetic effect and may be useful in reducing some of the pathologies associated with diabetes mellitus.