Plants (Jul 2021)

Evaluation of the Antidiabetic and Antihyperlipidemic Activity of <i>Spondias purpurea</i> Seeds in a Diabetic Zebrafish Model

  • Alethia Muñiz-Ramirez,
  • Abraham Heriberto Garcia-Campoy,
  • Rosa Martha Pérez Gutiérrez,
  • Efrén Venancio Garcia Báez,
  • José María Mota Flores

DOI
https://doi.org/10.3390/plants10071417
Journal volume & issue
Vol. 10, no. 7
p. 1417

Abstract

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Diabetes mellitus (DM) is a serious chronic degenerative disease characterized by high levels of glucose in the blood. It is associated with an absolute or relative deficiency in the production and/or action of insulin. Some of the complications associated with DM are heart disease, retinopathy, kidney disease, and neuropathy; therefore, new natural alternatives are being sought to control the disease. In this work, we evaluate the antidiabetic effect of Spondias purpurea seed methanol extract (CSM) in vitro and in a glucose-induced diabetic zebrafish model. CSM is capable of lowering blood glucose and cholesterol levels, as well as forming advanced glycation end-products, while not presenting toxic effects at the concentrations evaluated. These data show that CSM has a promising antidiabetic effect and may be useful in reducing some of the pathologies associated with diabetes mellitus.

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