The Chemical Compositions of Essential Oils Derived from <i>Cryptocarya alba</i> and <i>Laurelia sempervirens</i> Possess Antioxidant, Antibacterial and Antitumoral Activity Potential
Jorge Touma,
Myriam Navarro,
Betsabet Sepúlveda,
Alequis Pavon,
Gino Corsini,
Katia Fernández,
Claudia Quezada,
Angelo Torres,
María José Larrazabal-Fuentes,
Adrian Paredes,
Ivan Neira,
Matías Ferrando,
Flavia Bruna,
Alejandro Venegas,
Jessica Bravo
Affiliations
Jorge Touma
Facultad de Medicina, Centro de Investigación Biomédica, Universidad Diego Portales, Ejército 141, Santiago 837007, Chile
Myriam Navarro
Facultad de Medicina, Centro de Investigación Biomédica, Universidad Diego Portales, Ejército 141, Santiago 837007, Chile
Betsabet Sepúlveda
Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santos Dumont 964, Santiago 8880494, Chile
Alequis Pavon
Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Llano Subercaseaux 2801, Santiago 8910060, Chile
Gino Corsini
Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Llano Subercaseaux 2801, Santiago 8910060, Chile
Katia Fernández
Facultad de Medicina, Centro de Investigación Biomédica, Universidad Diego Portales, Ejército 141, Santiago 837007, Chile
Claudia Quezada
Laboratorio de Patología Molecular, Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5110566, Chile
Angelo Torres
Laboratorio de Patología Molecular, Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5110566, Chile
María José Larrazabal-Fuentes
Laboratorio Química Biológica, Departamento de Ciencias de los Alimentos y Nutrición, FACSA, Universidad de Antofagasta, Angamos 601, Antofagasta 1270300, Chile
Adrian Paredes
Laboratorio Química Biológica, Departamento de Ciencias de los Alimentos y Nutrición, FACSA, Universidad de Antofagasta, Angamos 601, Antofagasta 1270300, Chile
Ivan Neira
Laboratorio Química Biológica, Departamento de Ciencias de los Alimentos y Nutrición, FACSA, Universidad de Antofagasta, Angamos 601, Antofagasta 1270300, Chile
Matías Ferrando
Laboratorio de Hormonas y Biología del Cáncer, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CONICET CCT-Mendoza UNcuyo 5500, Argentina
Flavia Bruna
Laboratorio de Hormonas y Biología del Cáncer, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CONICET CCT-Mendoza UNcuyo 5500, Argentina
Alejandro Venegas
Facultad de Medicina, Centro de Investigación Biomédica, Universidad Diego Portales, Ejército 141, Santiago 837007, Chile
Jessica Bravo
Facultad de Medicina, Centro de Investigación Biomédica, Universidad Diego Portales, Ejército 141, Santiago 837007, Chile
Cryptocarya alba (Peumo; CA) and Laurelia sempervirens (Laurel; LS) are herbs native to the Chilean highlands and have historically been used for medicinal purposes by the Huilliches people. In this work, the essential oils were extracted using hydrodistillation in Clevenger apparatus and analyzed by GC-MS to determine their composition. The antioxidant capacity (AC) was evaluated in vitro. The cytotoxicity was determined using cell line cultures both non tumoral and tumoral. The toxicity was determined using the nematode Caenorhabditis elegans. The antimicrobial activity was evaluated against 52 bacteria using the agar disc diffusion method and the minimum inhibitory concentrations (MICs) were determined. The principal compounds found in C. alba essential oil (CA_EO) were α-terpineol (24.96%) and eucalyptol (21.63%) and were isazafrol (91.9%) in L. sempervirens essential oil (LS_EO). Both EOs showed antioxidant capacity in vitro. Both EO showed antibacterial activity against bacteria using. LS_EO showed more inhibitory effect on these cell lines respect to CA_EO. Both EOs showed toxicity against the nematode C.elegans at 3.12–50 mg/mL. The essential oils of CA and LS have an important bioactive potential in their antioxidant, antibacterial and cytotoxicity activity. Both essential oils could possibly be used in the field of natural medicine, natural food preservation, cosmetics, sanitation and plaguicides among others.