Hellenic Journal of Cardiology (Jan 2020)
The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design
- Spyridon G. Deftereos,
- Gerasimos Siasos,
- Georgios Giannopoulos,
- Dimitrios A. Vrachatis,
- Christos Angelidis,
- Sotiria G. Giotaki,
- Panagiotis Gargalianos,
- Helen Giamarellou,
- Charalampos Gogos,
- Georgios Daikos,
- Marios Lazanas,
- Pagona Lagiou,
- Georgios Saroglou,
- Nikolaos Sipsas,
- Sotirios Tsiodras,
- Dimitrios Chatzigeorgiou,
- Nikolaos Moussas,
- Anastasia Kotanidou,
- Nikolaos Koulouris,
- Evangelos Oikonomou,
- Andreas Kaoukis,
- Charalampos Kossyvakis,
- Konstantinos Raisakis,
- Katerina Fountoulaki,
- Mihalis Comis,
- Dimitrios Tsiachris,
- Eleni Sarri,
- Andreas Theodorakis,
- Luis Martinez-Dolz,
- Jorge Sanz-Sánchez,
- Bernhard Reimers,
- Giulio G. Stefanini,
- Michael Cleman,
- Dimitrios Filippou,
- Christoforos D. Olympios,
- Vlasios N. Pyrgakis,
- John Goudevenos,
- George Hahalis,
- Theofilos M. Kolettis,
- Efstathios Iliodromitis,
- Dimitrios Tousoulis,
- Christodoulos Stefanadis
Affiliations
- Spyridon G. Deftereos
- Medical School, National & Kapodistrian University of Athens, Athens, Greece; Corresponding author. Spiridon Deftereos, Rimini 1, Attikon Hospital, National and Kapodistrian University of Athens, Greece.
- Gerasimos Siasos
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Georgios Giannopoulos
- General Hospital of Athens “G.Gennimatas” Hospital, Athens, Greece
- Dimitrios A. Vrachatis
- Medical School, National & Kapodistrian University of Athens, Athens, Greece; Humanitas Clinical and Research Institute, Rozzano, Milan, Italy
- Christos Angelidis
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Sotiria G. Giotaki
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Panagiotis Gargalianos
- Athens Medical Center, Athens, Greece
- Helen Giamarellou
- Medical School, National & Kapodistrian University of Athens, Athens, Greece; Therapeutirion Hygeia, Athens, Greece
- Charalampos Gogos
- Medical School, University of Patras, Patra, Greece
- Georgios Daikos
- Medical School, National & Kapodistrian University of Athens, Athens, Greece; Mitera Hospital, Athens, Greece
- Marios Lazanas
- Metropolitan General Hospital, Athens, Greece
- Pagona Lagiou
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Georgios Saroglou
- Medical School, National & Kapodistrian University of Athens, Athens, Greece; Metropolitan Hospital, Athens, Greece
- Nikolaos Sipsas
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Sotirios Tsiodras
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Dimitrios Chatzigeorgiou
- Hellenic Air Force General Staff
- Nikolaos Moussas
- Athens Medical Center, Athens, Greece
- Anastasia Kotanidou
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Nikolaos Koulouris
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Evangelos Oikonomou
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Andreas Kaoukis
- General Hospital of Athens “G.Gennimatas” Hospital, Athens, Greece
- Charalampos Kossyvakis
- General Hospital of Athens “G.Gennimatas” Hospital, Athens, Greece
- Konstantinos Raisakis
- General Hospital of Athens “G.Gennimatas” Hospital, Athens, Greece
- Katerina Fountoulaki
- General Hospital of Elefsina “Thriasio”, Elefsina, Greece
- Mihalis Comis
- General Hospital of Elefsina “Thriasio”, Elefsina, Greece
- Dimitrios Tsiachris
- Athens Medical Center, Athens, Greece
- Eleni Sarri
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Andreas Theodorakis
- Missolonghi General Hospital “Chatzikosta”, Missolonghi, Greece
- Luis Martinez-Dolz
- Hospital Universitario y Politécnico La Fe, Valencia, Spain
- Jorge Sanz-Sánchez
- Humanitas Clinical and Research Institute, Rozzano, Milan, Italy; Hospital Universitario y Politécnico La Fe, Valencia, Spain
- Bernhard Reimers
- Humanitas Clinical and Research Institute, Rozzano, Milan, Italy
- Giulio G. Stefanini
- Humanitas Clinical and Research Institute, Rozzano, Milan, Italy
- Michael Cleman
- Yale University School of Medicine, New Haven, CT, USA
- Dimitrios Filippou
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Christoforos D. Olympios
- General Hospital of Elefsina “Thriasio”, Elefsina, Greece
- Vlasios N. Pyrgakis
- General Hospital of Athens “G.Gennimatas” Hospital, Athens, Greece
- John Goudevenos
- University of Ioannina, Ioannina, Greece
- George Hahalis
- Medical School, University of Patras, Patra, Greece
- Theofilos M. Kolettis
- University of Ioannina, Ioannina, Greece
- Efstathios Iliodromitis
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Dimitrios Tousoulis
- Medical School, National & Kapodistrian University of Athens, Athens, Greece
- Christodoulos Stefanadis
- Medical School, National & Kapodistrian University of Athens, Athens, Greece; Athens Medical Center, Athens, Greece
- Journal volume & issue
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Vol. 61,
no. 1
pp. 42 – 45
Abstract
Objective: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. Methods: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group. Results: Trial results will be disseminated through peer-reviewed publications and conference presentations. Conclusion: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790).
