Sestrins are evolutionarily conserved mediators of exercise benefits

Myungjin Kim; Alyson Sujkowski; Sim Namkoong; Bondong Gu; Tyler Cobb; Boyoung Kim; Allison H. Kowalsky; Chun-Seok Cho; Ian Semple; Seung-Hyun Ro; Carol Davis; Susan V. Brooks; Michael Karin; Robert J. Wessells; Jun Hee Lee

doi:10.1038/s41467-019-13442-5

Nature Communications (Jan 2020)

Sestrins are evolutionarily conserved mediators of exercise benefits

Myungjin Kim,
Alyson Sujkowski,
Sim Namkoong,
Bondong Gu,
Tyler Cobb,
Boyoung Kim,
Allison H. Kowalsky,
Chun-Seok Cho,
Ian Semple,
Seung-Hyun Ro,
Carol Davis,
Susan V. Brooks,
Michael Karin,
Robert J. Wessells,
Jun Hee Lee

Affiliations

Myungjin Kim: Department of Molecular & Integrative Physiology, University of Michigan
Alyson Sujkowski: Department of Physiology, Wayne State University School of Medicine
Sim Namkoong: Department of Molecular & Integrative Physiology, University of Michigan
Bondong Gu: Department of Molecular & Integrative Physiology, University of Michigan
Tyler Cobb: Department of Physiology, Wayne State University School of Medicine
Boyoung Kim: Department of Molecular & Integrative Physiology, University of Michigan
Allison H. Kowalsky: Department of Molecular & Integrative Physiology, University of Michigan
Chun-Seok Cho: Department of Molecular & Integrative Physiology, University of Michigan
Ian Semple: Department of Molecular & Integrative Physiology, University of Michigan
Seung-Hyun Ro: Department of Molecular & Integrative Physiology, University of Michigan
Carol Davis: Department of Molecular & Integrative Physiology, University of Michigan
Susan V. Brooks: Department of Molecular & Integrative Physiology, University of Michigan
Michael Karin: Department of Pharmacology, University of California San Diego
Robert J. Wessells: Department of Physiology, Wayne State University School of Medicine
Jun Hee Lee: Department of Molecular & Integrative Physiology, University of Michigan

DOI: https://doi.org/10.1038/s41467-019-13442-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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