Basosquamous Cell Carcinoma Developing from a Renal Transplantation Recipient

Abstract

We describe a case of basosquamous cell carcinoma arising from a 52-year-old Japanese renal transplantation recipient (RTR). In the present case, we investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study suggests some of the possible mechanisms for the carcinogenesis of cutaneous malignancy in RTRs.

Keywords

• Basosquamous cell carcinoma
• Immunosuppressive cells
• CD163+ M2 macrophage
• Carcinogenesis