Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2

Maria Luisa Barretta; Daniela Spano; Chiara D’Ambrosio; Romina Ines Cervigni; Andrea Scaloni; Daniela Corda; Antonino Colanzi

doi:10.1038/ncomms11727

Nature Communications (May 2016)

Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2

Maria Luisa Barretta,
Daniela Spano,
Chiara D’Ambrosio,
Romina Ines Cervigni,
Andrea Scaloni,
Daniela Corda,
Antonino Colanzi

Affiliations

Maria Luisa Barretta: Institute of Protein Biochemistry (IBP), National Research Council (CNR)
Daniela Spano: Institute of Protein Biochemistry (IBP), National Research Council (CNR)
Chiara D’Ambrosio: Proteomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, ISPAAM, National Research Council (CNR)
Romina Ines Cervigni: Institute of Protein Biochemistry (IBP), National Research Council (CNR)
Andrea Scaloni: Proteomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, ISPAAM, National Research Council (CNR)
Daniela Corda: Institute of Protein Biochemistry (IBP), National Research Council (CNR)
Antonino Colanzi: Institute of Protein Biochemistry (IBP), National Research Council (CNR)

DOI: https://doi.org/10.1038/ncomms11727
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The Golgi mitotic checkpoint couples Golgi inheritance with cell cycle transition, and regulates centrosomal recruitment of the mitotic kinase Aurora-A. Here the authors show that upon Golgi ribbon fragmentation in G2, Src phosphorylates Aurora-A at the Golgi, driving its localization to the centrosomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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