A green approach for the synthesis of α-Fe2O3 nanoparticles from Gardenia resinifera plant and it's In vitro hyperthermia application
V.C. Karade,
S.B. Parit,
V.V. Dawkar,
R.S. Devan,
R.J. Choudhary,
V.V. Kedge,
N.V. Pawar,
J.H. Kim,
A.D. Chougale
Affiliations
V.C. Karade
Optoelectronic Convergence Research Center, Department of Materials Science and Engineering, Chonnam National University, Gwangju, 500-757, South Korea; Department of Chemistry, The New College, Shivaji University, Kolhapur, 416012, India
S.B. Parit
Department of Chemistry, The New College, Shivaji University, Kolhapur, 416012, India
V.V. Dawkar
Biochemical Science Division, CSIR-National Chemical Laboratory, CSIR, Pune, India; Biotechnology and Pharma Division, MITCON Foundation, Shivajinagar, Pune 411005, India
R.S. Devan
Discipline of Metallurgy Engineering and Materials Science, Indian Institute of Technology Indore, Simrol, Indore, 453552, India
R.J. Choudhary
UGC-DAE Consortium for Scientific Research, Khandwa Road, Indore 452001, India
V.V. Kedge
Regrow, Regenerative Medical Services Pvt. Ltd, Lonavala, India
N.V. Pawar
Department of Botany, The New College, Shivaji University, Kolhapur, 416012, India
J.H. Kim
Optoelectronic Convergence Research Center, Department of Materials Science and Engineering, Chonnam National University, Gwangju, 500-757, South Korea
A.D. Chougale
Department of Chemistry, The New College, Shivaji University, Kolhapur, 416012, India; Corresponding author.
The Gardenia, traditional medicinal plant used from ancient time to increase appetite and other medicinal uses has been employed for the synthesis of superparamagnetic α-Fe2O3 nanoparticles (NPs). The plant extracts unveiled its bifunctional nature through the reducing ferric ions by phenolic groups and capping nature through the –OH bonding over the NPs surface. The prepared NPs exhibits α-Fe2O3 phase among iron oxides and spherical morphology with an average size around 5 nm. The magnetic measurements proved the superparamagnetic behavior of NPs with non-saturating MS value of 8.5 emu/g at room temperature (300 K). Further, the hyperthermia study reveals, the NPs achieved a temperature of 40 °C and 43 °C within 6 min and reaches up to 43 °C and 45 °C within 10 min only for 5 μg/mL and 10 μg/mL concentrations respectively. Based on the heating profile of NPs, the SAR values (167.7 Oe, 300 MHz) calculated and are found to be around 62.75 W/g and 24.38 W/g for 5 μg/mL and 10 μg/mL NPs concentrations respectively. Subsequently, these have been used for toxicity assays, which presented enhanced cytotoxic effects on human mesenchymal cells lines proving them as a potential candidate for the biomedical applications.
