Journal of Investigative Medicine High Impact Case Reports (Nov 2023)

Acquired Factor VII Deficiency Associated With Chronic Myeloid Leukemia Blast Crisis

  • Emily B. Wolf MD,
  • David Li MD,
  • Andre J. Fernandez MPAS, PA-C,
  • Lindsay B. Gardner MD,
  • Candido E. Rivera MD,
  • Ewa M. Wysokinska MD,
  • Marwan E. Shaikh MD,
  • Han W. Tun MD,
  • Vivek Roy MD,
  • Muhamad Alhaj Moustafa MD

DOI
https://doi.org/10.1177/23247096231209543
Journal volume & issue
Vol. 11

Abstract

Read online

Factor VII (FVII) is an important, vitamin K-dependent clotting factor. Acquired FVII deficiency is a rare entity that is associated with serious bleeding complications. We report a case of acquired FVII deficiency in a patient with recurrent chronic myeloid leukemia in blast crisis who developed bilateral retinal hemorrhages. The coagulopathy was corrected with the initiation of chemotherapy and subsequent reduction in peripheral blast count.