International Journal of General Medicine (Dec 2022)

Risk Factors of Pregnancy Failure in Infertile Patients Undergoing Assisted Reproductive Technology

  • Yi H,
  • Yang M,
  • Tang H,
  • Lin M

Journal volume & issue
Vol. Volume 15
pp. 8807 – 8817

Abstract

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Honggan Yi,1,2 Man Yang,1,2 Haiyu Tang,1,2 Mei Lin1,2 1Reproductive Medicine Center, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Honggan Yi, Reproductive Medicine Center, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, No. 63 Huangtang Road, Meijiang District, Meizhou, 514031, People’s Republic of China, Tel +86 753-2131-883, Email [email protected]: Infertile couples need to use assisted reproductive technology (ART) to give birth. However, pregnancy failure after ART is not uncommon. At present, the results of studies on the causes of pregnancy failure after ART are inconsistent.Methods: A retrospective cohort study involving 715 embryo transfer cycles was conducted at the Reproductive Medicine Center of Meizhou People’s Hospital, from December 2015 to June 2022. According to the pregnancy, they were divided into clinical pregnancy group and pregnancy failure group. The relationship between demographic characteristics and pregnancy status between the two groups was analyzed.Results: The pregnancy failure rate after ART was 49.7% (355/715). There were statistically significant distribution differences of maternal age, paternal age, COH protocols, and number of embryos transferred between clinical pregnancy and pregnancy failure groups (all P 35 years old vs ≤ 35 years old: OR 2.173, 95% CI: 1.386– 3.407, P=0.001), and GnRH-a short protocol (GnRH-a short protocol vs GnRH-a long protocol: OR 2.139, 95% CI: 1.127– 4.058, P=0.020) may increase risk of pregnancy failure in ART pregnancies, while two embryos transferred (two embryos transferred vs one embryo transferred: OR 0.563, 95% CI: 0.377– 0.839, P=0.005) may reduce risk of pregnancy failure. In addition, high maternal age, GnRH antagonist protocol, and GnRH-a short protocol may increase risk of implantation failure, while two embryos transferred may reduce risk of implantation failure. And high maternal age may increase risk of biochemical pregnancy.Conclusion: The risk of pregnancy failure increased in ART cycles with maternal age > 35 years old and GnRH-a short protocol, while reduced with two embryos transferred.Keywords: assisted reproductive technology, risk factors, pregnancy failure, infertility, miscarriage

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