Nature Communications (Jan 2017)
Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
- David Braig,
- Tracy L. Nero,
- Hans-Georg Koch,
- Benedict Kaiser,
- Xiaowei Wang,
- Jan R. Thiele,
- Craig J. Morton,
- Johannes Zeller,
- Jurij Kiefer,
- Lawrence A. Potempa,
- Natalie A. Mellett,
- Luke A. Miles,
- Xiao-Jun Du,
- Peter J. Meikle,
- Markus Huber-Lang,
- G. Björn Stark,
- Michael W. Parker,
- Karlheinz Peter,
- Steffen U. Eisenhardt
Affiliations
- David Braig
- Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg
- Tracy L. Nero
- ACRF Rational Drug Discovery Centre, St Vincent’s Institute of Medical Research
- Hans-Georg Koch
- Institute for Biochemistry and Molecular Biology and Spemann-Graduate School for Biology and Medicine University of Freiburg, Medical Faculty of the University of Freiburg
- Benedict Kaiser
- Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg
- Xiaowei Wang
- Baker IDI Heart and Diabetes Institute
- Jan R. Thiele
- Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg
- Craig J. Morton
- ACRF Rational Drug Discovery Centre, St Vincent’s Institute of Medical Research
- Johannes Zeller
- Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg
- Jurij Kiefer
- Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg
- Lawrence A. Potempa
- College of Pharmacy, Roosevelt University
- Natalie A. Mellett
- Baker IDI Heart and Diabetes Institute
- Luke A. Miles
- ACRF Rational Drug Discovery Centre, St Vincent’s Institute of Medical Research
- Xiao-Jun Du
- Baker IDI Heart and Diabetes Institute
- Peter J. Meikle
- Baker IDI Heart and Diabetes Institute
- Markus Huber-Lang
- Department of Traumatology, Hand, Plastic, and Reconstructive Surgery, Center of Surgery, University of Ulm
- G. Björn Stark
- Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg
- Michael W. Parker
- ACRF Rational Drug Discovery Centre, St Vincent’s Institute of Medical Research
- Karlheinz Peter
- Baker IDI Heart and Diabetes Institute
- Steffen U. Eisenhardt
- Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg
- DOI
- https://doi.org/10.1038/ncomms14188
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
C-reactive protein is a pentameric protein secreted by the liver in response to injury and infection. Here Braiget al. show that conformational changes in CRP on the surface of monocyte-derived microvesicles enable binding of complement C1q and lead to activation of the complement cascade and aggravation of inflammation.
