Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy; Corresponding author. I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, Roma, 00161, Italy.
Alessandra Oliva
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Roberto Cangemi
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Giancarlo Ceccarelli
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Pasquale Pignatelli
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Roberto Carnevale
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy; Mediterranea Cardiocentro, 80122 Napoli, Italy
Vittoria Cammisotto
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Miriam Lichtner
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Francesco Alessandri
Department of General Surgery Paride Stefanini, Sapienza University of Rome, Rome, Italy
Massimiliano De Angelis
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Maria Claudia Miele
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Gabriella D'Ettorre
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Franco Ruberto
Department of General Surgery Paride Stefanini, Sapienza University of Rome, Rome, Italy
Mario Venditti
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Francesco Pugliese
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Claudio Maria Mastroianni
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.
