Nox2 activation in Covid-19

Francesco Violi; Alessandra Oliva; Roberto Cangemi; Giancarlo Ceccarelli; Pasquale Pignatelli; Roberto Carnevale; Vittoria Cammisotto; Miriam Lichtner; Francesco Alessandri; Massimiliano De Angelis; Maria Claudia Miele; Gabriella D'Ettorre; Franco Ruberto; Mario Venditti; Francesco Pugliese; Claudio Maria Mastroianni

Redox Biology (Sep 2020)

Nox2 activation in Covid-19

Francesco Violi,
Alessandra Oliva,
Roberto Cangemi,
Giancarlo Ceccarelli,
Pasquale Pignatelli,
Roberto Carnevale,
Vittoria Cammisotto,
Miriam Lichtner,
Francesco Alessandri,
Massimiliano De Angelis,
Maria Claudia Miele,
Gabriella D'Ettorre,
Franco Ruberto,
Mario Venditti,
Francesco Pugliese,
Claudio Maria Mastroianni

Affiliations

Francesco Violi: Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy; Corresponding author. I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, Roma, 00161, Italy.
Alessandra Oliva: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Roberto Cangemi: Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Giancarlo Ceccarelli: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Pasquale Pignatelli: Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Roberto Carnevale: Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy; Mediterranea Cardiocentro, 80122 Napoli, Italy
Vittoria Cammisotto: Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Miriam Lichtner: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Francesco Alessandri: Department of General Surgery Paride Stefanini, Sapienza University of Rome, Rome, Italy
Massimiliano De Angelis: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Maria Claudia Miele: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Gabriella D'Ettorre: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Franco Ruberto: Department of General Surgery Paride Stefanini, Sapienza University of Rome, Rome, Italy
Mario Venditti: Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Francesco Pugliese: Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Claudio Maria Mastroianni: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy

Journal volume & issue: Vol. 36
p. 101655

Abstract

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Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.

Published in Redox Biology

ISSN: 2213-2317 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: http://www.journals.elsevier.com/redox-biology/

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