International Journal of General Medicine (Jan 2022)

Gelsolin Can Be a Prognostic Biomarker and Correlated with Immune Infiltrates in Gastric Cancer

  • Wu Y,
  • Zheng J,
  • Yan Y,
  • Liu J,
  • Zhou Y

Journal volume & issue
Vol. Volume 15
pp. 927 – 936

Abstract

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Yingmei Wu,1,2,* Junhui Zheng,1,2,* Yanhua Yan,1,2 Jiduo Liu,3 Yingchun Zhou3 1Guangzhou University of Chinese Medicine, Guangzhou, 510000, People’s Republic of China; 2Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510000, People’s Republic of China; 3Department of Clinical Laboratory, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingchun Zhou; Jiduo LiuDepartment of Clinical Laboratory, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510000, People’s Republic of ChinaEmail [email protected]; [email protected]: Gelsolin (GSN) is the most widely expressed actin-severing protein in humans, which could regulate cell morphology, differentiation, movement and apoptosis. This study aims to explore the GSN as a prognostic biomarker of stomach adenocarcinoma (STAD).Methods: In this study, we used several online databases to comprehensively analyze the role of GSN in STAD. Oncomine and HPA databases were used to explore the GSN expression in various cancer, especially in gastric cancer. Then, UALCAN database was used to evaluate the relationship between GSN expression and promoter methylation in clinical characteristics. Finally, we used TIMER to analyze the correlation between GSN expression and immune infiltrates in gastric cancer.Results: GSN was down-regulated in gastric cancer, and decreased expression of GSN was related to worse survival. The GSN expression was significantly related to tumor purity in STAD and significantly correlated with infiltrating level of various immune cells, especially the dendritic cells.Conclusion: Our study proposes that GSN can be served as the biomarker of disease and neoantigen for STAD treatment, which can improve the deficiency of disease-specific targeted therapies currently exist.Keywords: gelsolin, gastric cancer, prognosis, immune cell infiltration

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