Conformational dynamics and kinetics of protein interactions by nuclear magnetic resonance

Abstract

Structural information of protein complexes is fundamental for the rational drug design and improvement of vaccines and biosensors. Also, protein misassembly can have severe biological consequences. Here we discuss the challenges of studying protein complexes and show examples of systems characterized using NMR.

Keywords

• Protein complexes
• Dynamics
• NMR
• Recognition
• Allostery