Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma

Abstract

Pinggui Chen,1 Yaoxuan Li,2 Yunyan Dai,1 Zhiming Wang,1 Yunpeng Zhou,1 Yi Wang,1 Gaopeng Li1 1Department of Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, People’s Republic of China; 2Department of School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Gaopeng Li, Email [email protected]: Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and the primary cause of death in cancer cases, with significant public health concern worldwide. Despite the overall decline in the incidence and mortality rates of HCC in recent years in recent years, the emergence of metabolic liver disease-related HCC is causing heightened concern, especially in countries like the United States, the United Kingdom, and P.R. China. The escalation of metabolic liver disease-related HCC is attributed to a combination of factors, including genetic predisposition, lifestyle choices, and changes in the living environment. However, the pathogenesis of metabolic liver disease-associated HCC remains imperfect. In this review, we encapsulate the latest advances and essential aspects of the pathogenesis of metabolic liver disease-associated HCC, including alcoholic liver disease (ALD), metabolic dysfunction–associated steatotic liver disease (MASLD), and inherited metabolic liver diseases.Keywords: hepatocellular carcinoma, metabolic liver disease, pathogenesis, alcoholic liver disease, metabolic dysfunction–associated steatotic liver disease

Keywords

• hepatocellular carcinoma
• metabolic liver disease
• pathogenesis
• alcoholic liver disease
• metabolic dysfunction–associated steatotic liver disease