Sex differences in atrial remodeling and its relationship with myocardial fibrosis in hypertrophic obstructive cardiomyopathy

Xuanye Bi; Xuanye Bi; Yanyan Song; Chengzhi Yang; Yunhu Song; Shihua Zhao; Shubin Qiao; Jinying Zhang

doi:10.3389/fcvm.2022.947975

Frontiers in Cardiovascular Medicine (Nov 2022)

Sex differences in atrial remodeling and its relationship with myocardial fibrosis in hypertrophic obstructive cardiomyopathy

Xuanye Bi,
Xuanye Bi,
Yanyan Song,
Chengzhi Yang,
Yunhu Song,
Shihua Zhao,
Shubin Qiao,
Jinying Zhang

Affiliations

Xuanye Bi: Henan Province Key Laboratory of Cardiac Injury and Repair, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Xuanye Bi: State Key Laboratory of Cardiovascular Disease, Department of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yanyan Song: State Key Laboratory of Cardiovascular Disease, Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Chengzhi Yang: State Key Laboratory of Cardiovascular Disease, Department of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yunhu Song: State Key Laboratory of Cardiovascular Disease, Department of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Shihua Zhao: State Key Laboratory of Cardiovascular Disease, Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Shubin Qiao: State Key Laboratory of Cardiovascular Disease, Department of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Jinying Zhang: Henan Province Key Laboratory of Cardiac Injury and Repair, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

DOI: https://doi.org/10.3389/fcvm.2022.947975
Journal volume & issue: Vol. 9

Abstract

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BackgroundThis study aimed to explore the effect of sex on left atrial (LA) remodeling and its relationship with myocardial fibrosis in patients with hypertrophic obstructive cardiomyopathy (HOCM).Methods and resultsA total of 85 patients with HOCM were enrolled. Myocardial fibrosis was quantified by the collagen volume fraction (CVF) in myocardial samples. The early atrial peak of emptying rate (PER-E) was assessed by LA volume/time (V/t) curves derived from cardiac magnetic resonance (CMR) imaging analysis. The PER-E index was PER-E normalized by left ventricular (LV) filling volume. Patients with HOCM showed a lower PER-E index than healthy controls (P = 0.027). Compared with men, the PER-E (P < 0.001) and the PER-E indexes (P = 0.012) in women were lower. In CVF-stratified subgroups, a sex difference in the PER-E index was eliminated (P > 0.05). The CVF was correlated with the PER-E and PER-E indexes in both sexes (all P-values were <0.05). In multivariate regression analysis, sex (P = 0.007) and CVF (P < 0.001) were independently correlated with PER-E (all P-values were <0.05).ConclusionPatients with HOCM presented LA reverse remodeling. Impaired LA function was more common in female patients with HOCM due to their susceptibility to myocardial fibrosis.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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