Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy

Shota Sawaguchi, MD; Nobuhiro Terao, MD, PhD; Naoya Imanaga, MD; Sorako Wakugawa, MD; Tamaki Tamashiro, MD; Yukihide Yamauchi; Hideki Koizumi, MD, PhD

Ophthalmology Science (Jun 2022)

Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy

Shota Sawaguchi, MD,
Nobuhiro Terao, MD, PhD,
Naoya Imanaga, MD,
Sorako Wakugawa, MD,
Tamaki Tamashiro, MD,
Yukihide Yamauchi,
Hideki Koizumi, MD, PhD

Affiliations

Shota Sawaguchi, MD: Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Nobuhiro Terao, MD, PhD: Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Naoya Imanaga, MD: Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Sorako Wakugawa, MD: Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Tamaki Tamashiro, MD: Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Yukihide Yamauchi: Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Hideki Koizumi, MD, PhD: Correspondence: Hideki Koizumi, MD, PhD, Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Nakagami-gun, Okinawa 903-0215, Japan.; Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan

Journal volume & issue: Vol. 2, no. 2
p. 100124

Abstract

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Purpose: To evaluate and compare the scleral thickness of patients with idiopathic central serous chorioretinopathy (iCSC) and steroid-induced central serous chorioretinopathy (sCSC) using anterior-segment OCT. Design: Retrospective, comparative study. Participants: One hundred ten eyes of 110 patients with central serous chorioretinopathy. Methods: We classified the patients into iCSC and sCSC groups and compared age, sex, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness. We measured scleral thickness 6 mm posterior to the scleral spur in 4 directions. Main Outcome Measure: Scleral thickness in sCSC eyes. Results: We enrolled 96 and 14 eyes in the iCSC and sCSC groups, respectively. The sCSC group included a greater proportion of women than the iCSC group (42.9% and 13.5%, respectively; P = 0.020). We observed no between-group differences in age, spherical equivalent, axial length, or SCT. Univariate analysis revealed that the sCSC group had a significantly thinner sclera at the superior (423.4 μm vs. 346.6 μm; P < 0.001), temporal (440.1 μm vs. 399.4 μm; P = 0.020), inferior (450.1 μm vs. 395.3 μm; P = 0.001), and nasal (436.6 μm vs. 391.9 μm; P = 0.002) points than the iCSC group. Multivariate analyses revealed that female sex (odds ratio, 4.322; 95% confidence interval, 1.025–18.224; P = 0.046) and mean scleral thickness (odds ratio, 0.972; 95% confidence interval, 0.955–0.990; P = 0.002) were significantly associated with sCSC. Conclusions: The scleral thickness of eyes in the sCSC group was significantly thinner than that in the iCSC group. This suggests that the sclera has less involvement in the pathogenesis of sCSC than in that of iCSC.

Published in Ophthalmology Science

ISSN: 2666-9145 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Ophthalmology
Website: https://www.journals.elsevier.com/ophthalmology-science/

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