Efficacy and toxicity of SEAM (semustine, etoposide, cytarabine, and melphalan) conditioning regimen followed by autologous stem cell transplantation in lymphoma
Lihong Zhang,
Haifei Yang,
Chongsheng Qian,
Jihao Zhou,
Qian Zhu,
Yibin Jiang,
Shuo Liu,
Xiaochen Chen,
Ting Xu,
Changju Qu,
Caixia Li,
Zhengming Jin,
Jianhong Chu,
Xinyou Zhang,
Depei Wu,
Haiwen Huang
Affiliations
Lihong Zhang
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Haifei Yang
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Chongsheng Qian
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Jihao Zhou
The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, Department of Hematology, Shenzhen, Guangdong, People’s Republic of China
Qian Zhu
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Yibin Jiang
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Shuo Liu
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Xiaochen Chen
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Ting Xu
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Changju Qu
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Caixia Li
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Zhengming Jin
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Jianhong Chu
Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu, People’s Republic of China
Xinyou Zhang
The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, Department of Hematology, Shenzhen, Guangdong, People’s Republic of China
Depei Wu
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Haiwen Huang
First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, Jiangsu, People’s Republic of China
Objectives The aim of this retrospective study was to evaluate the safety and efficacy of SEAM regimen followed by auto-SCT in lymphoma.Patients and methods We retrospectively reviewed the records of patients with lymphoma who underwent auto-SCT with SEAM conditioning regimen from January 2010 to June 2018 at our centre. In total, 97 patients were analysed.Results The median time to neutrophil engraftment and platelet engraftment was 9.5 days (range, 7–15 days) and 12 days (range, 7–25 days), respectively. Grade 3–4 nausea/vomiting, mucositis and diarrhoea were observed in 21.6%, 36.1%, and 11.3% of patients, respectively. Treatment-related mortality at 100 days occurred in 2 patients (2.1%). After a median follow-up time of 53.9 months, the 3-year incidence of disease relapse or progression was 34%. The estimated progression-free survival and overall survival at 3 years were 62% and 75%, respectively. Compared with previous studies using BEAM as the conditioning regimen, this study shows that the SEAM regimen has a comparable efficacy and safety profile.Conclusions The SEAM regimen is feasible and might be an ideal alternative to BEAM regimen for lymphoma auto-SCT.
