The role of melatonin in pathogenesis of cardiovascular diseases

Abstract

The results presented, of laboratory and clinical studies of melatonine role in pathogenesis of cardiovascular diseases as arterial hypertension, coronary pathology. The influence of melatonin on atherogenesis is described, its impact on platelet aggregation. Increase of melatonin production in cardiovascular patients is probably the result of compensatory mechanisms activation at the stage of functional disorders with further exhaustion of compensatory mechanisms towards somatic disease development. As the severity of cardiovascular pathology increases, general production of melatonin declines, as well as its rhythmic of production turns disordered.

Keywords

• melatonin
• arterial hypertension
• coronary heart disease
• atherosclerosis