Nature Communications (Apr 2021)
Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
Abstract
Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagocytes.