Кубанский научный медицинский вестник (Oct 2016)

STUDY OF EFFECT PREKONDITSIONIRUYUSCHEGO RESVERATROL AND NICORANDIL IN THE CORRECTION OF ADMA-LIKE PRE-ECLAMPSIA

  • V. V. Gureev,
  • G. A. Lazareva,
  • E. G. Stupakova,
  • L. A. Zhilinkova

Journal volume & issue
no. 5
pp. 30 – 33

Abstract

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The search for new drugs have prekonditsioniruyuschimi properties is a promising direction of modern pharmacology. We investigated the role of prekonditsioniruyuschih properties of resveratrol and nicorandil in the correction of ADMA-like pre-eclampsia. Keeping resveratrol (2 mg/kg) and nicorandil (2x10 mg/kg) led to a marked correction of morphological and functional disorders arise in modeling experimental preeclampsia. Concomitant administration of a blocker of K+ ATP-channels -glibenclamide (50 mg/kg) with the test drugs practically eliminate protective effects of resveratrol and nicorandil. These data suggest a significant role prekonditsioniruyuschih properties of resveratrol and nicorandil in the implementation of the positive effects of the correction of morphological and functional disorders arise when modeling ADMA-like pre-eclampsia.

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