Остеопороз и остеопатии (Aug 2009)

DINAMIKA MINERAL'NOY PLOTNOSTI KOSTI U RETsIPIENTOV POSLE PERESADKI PEChENI

  • I P Ermakova,
  • Ya G Moysyuk,
  • V P Buzulina,
  • T K Koliashvili,
  • E B Yaroshenko,
  • M N Kornilov,
  • I A Pronchenko,
  • N P Shmerko

DOI
https://doi.org/10.14341/osteo200922-4
Journal volume & issue
Vol. 12, no. 2
pp. 2 – 4

Abstract

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Axial and periferal bone mineral density (BMD) was estimated by DXA twice within 1-47 months in 16 patients following orthotopic liver transplantation (OLT). Osteoporosis and osteopenia of lumbar spine and hip were identified in the first examination of all 9 recipients (group 1) with primary biliary cirrhosis (PBC) and in 5 out of 7 (71%) patients with viral hepatitic cirrhosis (group 2). Recipients which were firstly examined within 1-7 months following OLT (subgroups 1A, 2A) through 9±2.8 months showed in 1A axial BMD elevation (on 20.7+13.2% ; P=0.024) and in 2A axial so as hip BMD elevation (on 10.5+2.7%;P=0.001 and 8.1+5.9%;P< 0.05). Recipients which were examined later 18 months after OLT demonstrated no increase in BMD (subgroups 1B and 2B). Moreover two of them with PBC showed decrease in BMD, probably, as a result of transplant dysfunction and immunosuppression with glucocorticoids.

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