Nature Communications (Nov 2022)

N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA

  • Xiang Zhang,
  • Huilong Yin,
  • Xiaofang Zhang,
  • Xunliang Jiang,
  • Yongkang Liu,
  • Haolin Zhang,
  • Yingran Peng,
  • Da Li,
  • Yanping Yu,
  • Jinbao Zhang,
  • Shuli Cheng,
  • Angang Yang,
  • Rui Zhang

DOI
https://doi.org/10.1038/s41467-022-34808-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

Here the authors find that the mRNA of GYS2, the liver-specific glycogen synthase, is a substrate of METTL3 and IGF2BP2 and that m6A-mediated regulation of Gys2 mRNA is critical for the maintenance of liver glycogenesis in mammals during growth, such as mice and rats.