Increased hindbrain motion in Chiari I malformation patients measured through 3D amplified MRI (3D aMRI)

Javid Abderezaei; Fargol Rezayaraghi; Aymeric Pionteck; Ya-Chen Chuang; Alejandro Carrasquilla; Gizem Bilgili; Tianyi Ren; Tyson Lam; Tse-An Lu; Miriam Scadeng; Patrick Fillingham; Peter Morgenstern; Michael R. Levitt; Richard G. Ellenbogen; Yang Yang; Samantha J. Holdsworth; Raj Shrivastava; Mehmet Kurt

Brain Multiphysics (Dec 2024)

Increased hindbrain motion in Chiari I malformation patients measured through 3D amplified MRI (3D aMRI)

Javid Abderezaei,
Fargol Rezayaraghi,
Aymeric Pionteck,
Ya-Chen Chuang,
Alejandro Carrasquilla,
Gizem Bilgili,
Tianyi Ren,
Tyson Lam,
Tse-An Lu,
Miriam Scadeng,
Patrick Fillingham,
Peter Morgenstern,
Michael R. Levitt,
Richard G. Ellenbogen,
Yang Yang,
Samantha J. Holdsworth,
Raj Shrivastava,
Mehmet Kurt

Affiliations

Javid Abderezaei: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA
Fargol Rezayaraghi: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA
Aymeric Pionteck: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA
Ya-Chen Chuang: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA
Alejandro Carrasquilla: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Gizem Bilgili: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA
Tianyi Ren: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA; Corresponding author.
Tyson Lam: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA
Tse-An Lu: Department of Biostatistics, Boston University, Boston, MA, USA
Miriam Scadeng: Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences & Centre for Brain Research University of Auckland, Auckland, New Zealand
Patrick Fillingham: Department of Neurological Surgery, University of Washington, Seattle, WA, USA; Stroke and Applied Neuroscience Center, University of Washington, Seattle, WA, USA
Peter Morgenstern: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Michael R. Levitt: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA; Department of Neurological Surgery, University of Washington, Seattle, WA, USA; Stroke and Applied Neuroscience Center, University of Washington, Seattle, WA, USA
Richard G. Ellenbogen: Department of Neurological Surgery, University of Washington, Seattle, WA, USA; Stroke and Applied Neuroscience Center, University of Washington, Seattle, WA, USA
Yang Yang: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Samantha J. Holdsworth: Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences & Centre for Brain Research University of Auckland, Auckland, New Zealand; Mātai Medical Research Institute, Gisborne-Tairāwhiti, New Zealand
Raj Shrivastava: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Mehmet Kurt: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Journal volume & issue: Vol. 7
p. 100100

Abstract

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Chiari Malformation type 1 (CM-I) is a neurological disorder characterized by morphological defects including excessive cerebellar tonsillar ectopia and associated manifestations. We used 3D amplified MRI on a cohort of healthy and CM-I subjects to investigate the brain’s intrinsic motion, its association with the morphology and patient’s symptomatology, and surgical outcomes. We observed that the regional brain motion in CM-I was significantly higher than that of the healthy subjects, with anterior-posterior (AP) and superior-inferior (SI) displacements in cerebellar tonsils and medulla having the highest differences between the healthy and CM-I (∼45%–∼73% increased motion in the CM-I group). Interestingly, we found the ratio of neural tissue in the foramen magnum to be directly correlated with the SI tonsillar motion (r=0.58). Tonsillar herniation was directly correlated with the AP motion of the tonsils (r=0.61), and AP and medial-lateral (ML) motions of the medulla (r=0.66, and r=0.57). Subjects with higher tonsillar ML motion prior to surgery showed improved outcome (p=0.03, and AUC=0.95). Although we did not observe a significant correlation between the brains motion and morphometrics on the CM-I symptoms (perhaps due to our small sample size), illustrative cases increase our hope for the development of a future tool based on brain biomechanics.

Published in Brain Multiphysics

ISSN: 2666-5220 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-multiphysics

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