Prevention and treatment of cancers by tumor antigen-expressing Staphylococcus epidermidis

Abstract

ABSTRACTIn a recent paper in Science, Chen et al. reported the genetic engineering of S. epidermidis expressing tumor cross-reactive antigens that trigger T cell responses and exhibit anticancer effects after topical administration. Here we discuss direct local effects and indirect systemic effects of exposure to engineered S. epidermidis strains.

Keywords

• Immunotherapy
• Microbiome
• Immunity