Laboratory on Structure and Properties of Polymers, Department of Pharmaceutical and Applied Organic Chemistry, Faculty of Chemistry and Pharmacy, Sofia University “St. Kl. Ohridski”, 1 J. Bourchier Blvd., 1164 Sofia, Bulgaria
Katerina Todorova
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria
Tanya Zhivkova
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria
Rositsa Milcheva
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria
Dimitar Ivanov
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria
Petar Dimitrov
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria
Radostina Alexandrova
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria
Elena Vassileva
Laboratory on Structure and Properties of Polymers, Department of Pharmaceutical and Applied Organic Chemistry, Faculty of Chemistry and Pharmacy, Sofia University “St. Kl. Ohridski”, 1 J. Bourchier Blvd., 1164 Sofia, Bulgaria
The study reports the synthesis and characterization of novel triple stimuli responsive interpenetrating polymer network (IPN) based on two polyzwitterionic networks, namely of poly(carboxybetaine methacrylate) and poly(sulfobetaine methacrylate). The zwitterionic IPN hydrogel demonstrates the ability to expand or shrink in response to changes in three “biological” external stimuli such as temperature, pH, and salt concentration. The IPN hydrogel shows good mechanical stability. In addition, other important features such as non-cytotoxicity and antibiofouling activity against three widespread bacteria as P. Aeruginosa, A. Baumanii, and K. Pneumoniae are demonstrated. The in vivo behavior of the novel zwitterionic IPN hydrogel suggests that this smart material has very good potential as a biomaterial.
