Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p

Ning Ding; Yu Zhang; Mengna Huang; Jianfeng Liu; Chonglong Wang; Chun Zhang; Jinkang Cao; Qin Zhang; Li Jiang

doi:10.1038/s42003-022-04263-2

Communications Biology (Dec 2022)

Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p

Ning Ding,
Yu Zhang,
Mengna Huang,
Jianfeng Liu,
Chonglong Wang,
Chun Zhang,
Jinkang Cao,
Qin Zhang,
Li Jiang

Affiliations

Ning Ding: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural University
Yu Zhang: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural University
Mengna Huang: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural University
Jianfeng Liu: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural University
Chonglong Wang: Key Laboratory of Pig Molecular Quantitative Genetics of Anhui Academy of Agricultural Sciences, Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences
Chun Zhang: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural University
Jinkang Cao: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural University
Qin Zhang: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural University
Li Jiang: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural University

DOI: https://doi.org/10.1038/s42003-022-04263-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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By identifying circ-CREBBP out of differently expressed circRNAs in seminal plasma extracellular vesicles from boars with high and low sperm motility, the circRNA is shown to play a role in sperm survival and apoptosis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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