Pan-Cancer Analysis of the Associations of TGFBI Expression With Prognosis and Immune Characteristics

Yun Chen; Han Zhao; Han Zhao; Han Zhao; Yao Feng; Qin Ye; Jing Hu; Yue Guo; Yunzhi Feng

doi:10.3389/fmolb.2021.745649

Frontiers in Molecular Biosciences (Oct 2021)

Pan-Cancer Analysis of the Associations of TGFBI Expression With Prognosis and Immune Characteristics

Yun Chen,
Han Zhao,
Han Zhao,
Han Zhao,
Yao Feng,
Qin Ye,
Jing Hu,
Yue Guo,
Yunzhi Feng

Affiliations

Yun Chen: Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China
Han Zhao: Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China
Han Zhao: Laboratory of Myopia, NHC Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, Shanghai, China
Han Zhao: Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China
Yao Feng: Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China
Qin Ye: Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China
Jing Hu: Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China
Yue Guo: Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China
Yunzhi Feng: Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fmolb.2021.745649
Journal volume & issue: Vol. 8

Abstract

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Transforming growth factor-beta-induced (TGFBI) protein has important roles in tumor growth, metastasis, and immunity. However, there is currently no pan-cancer evidence regarding TGFBI. In this study, we conducted a pan-cancer analysis of TGFBI mRNA and protein expression and prognoses of various cancer types using public databases. We also investigated the associations of TGFBI expression with tumor microenvironment (TME) components, immune cell infiltration, tumor mutational burden (TMB), and microsatellite instability (MSI), along with the TGFBI genetic alteration types. The results showed that TGFBI expression varied among different cancer types, and it was positively or negatively related to prognosis in various cancers. TGFBI expression was also significantly correlated with TME components, TMB, MSI, immune cell infiltration, and immunoinhibitory and immunostimulatory gene subsets. These findings indicate that TGFBI participates in various immune responses and it may function as a prognostic marker in various cancers. The findings may be useful for developing immunotherapies that target TGFBI.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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