Проблемы особо опасных инфекций (Jun 2011)

Infectious Properties of Avian Influenza A/H5N1 Virus Strains Studied by means of Experiments on Mice

  • A. A. Sergeev,
  • O. V. P`yankov,
  • O. K. Demina,
  • O. G. P`yankova,
  • E. I. Ryabchikova,
  • A. P. Agafonov,
  • A. N. Sergeev

DOI
https://doi.org/10.21055/0370-1069-2011-3(109)-40-42
Journal volume & issue
Vol. 0, no. 3(109)
pp. 40 – 42

Abstract

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The studied strains of avian influenza virus A/H5N1 (AIV), isolated in the territory of the Russian Federation and CIS countries, can be classified into three groups according to their virulence for mice after intranasal and aerosol challenging: highly virulent strains [50 % aerosol lethal dose (ALD50) - 4,5 lg EID50] - A/Turkey/Suzdalka/Nov-1/2005 and A/Chicken/Suzdalka/Nov-11/2005. Registered is the high degree of correlation (r = 0,89 ) between the indexes of virulence of the strains, obtained by means of intranasal and aerosol challenging of mice. The primary target-cells in mice, respiratory-infected by AIV, are the respiratory tract ciliated cells and pneumonocytes of I, II types.

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