Nature Communications (Jul 2022)
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera
- Raveen Rathnasinghe,
- Sonia Jangra,
- Chengjin Ye,
- Anastasija Cupic,
- Gagandeep Singh,
- Carles Martínez-Romero,
- Lubbertus C. F. Mulder,
- Thomas Kehrer,
- Soner Yildiz,
- Angela Choi,
- Stephen T. Yeung,
- Ignacio Mena,
- Virginia Gillespie,
- Jana De Vrieze,
- Sadaf Aslam,
- Daniel Stadlbauer,
- David A. Meekins,
- Chester D. McDowell,
- Velmurugan Balaraman,
- Michael J. Corley,
- Juergen A. Richt,
- Bruno G. De Geest,
- Lisa Miorin,
- PVI study group,
- Florian Krammer,
- Luis Martinez-Sobrido,
- Viviana Simon,
- Adolfo García-Sastre,
- Michael Schotsaert
Affiliations
- Raveen Rathnasinghe
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Sonia Jangra
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Chengjin Ye
- Texas Biomedical Research Institute
- Anastasija Cupic
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Gagandeep Singh
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Carles Martínez-Romero
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Lubbertus C. F. Mulder
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Thomas Kehrer
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Soner Yildiz
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Angela Choi
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Stephen T. Yeung
- Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York
- Ignacio Mena
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Virginia Gillespie
- Center for Comparative Medicine and Surgery, Icahn School of Medicine at Mount Sinai New York
- Jana De Vrieze
- Department of Pharmaceutics, Ghent University
- Sadaf Aslam
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Daniel Stadlbauer
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- David A. Meekins
- Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University
- Chester D. McDowell
- Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University
- Velmurugan Balaraman
- Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University
- Michael J. Corley
- Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York
- Juergen A. Richt
- Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University
- Bruno G. De Geest
- Department of Pharmaceutics, Ghent University
- Lisa Miorin
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- PVI study group
- Florian Krammer
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Luis Martinez-Sobrido
- Texas Biomedical Research Institute
- Viviana Simon
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Adolfo García-Sastre
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- Michael Schotsaert
- Department of Microbiology, Icahn School of Medicine at Mount Sinai New York
- DOI
- https://doi.org/10.1038/s41467-022-30763-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Here, Rathnasinghe et al. characterize the pathogenesis of a mouse-adapted SARS-CoV-2 in infected obese and aged mice, and identify mutations that are present in SARS-CoV-2 variants of concern, associated with higher transmissibility.
