Clinical Ophthalmology (Jun 2008)

Potential bias in ophthalmic pharmaceutical clinical trials

  • Paul Varner

Journal volume & issue
Vol. 2008, no. Issue 2
pp. 401 – 411

Abstract

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Paul VarnerJohn J Pershing Veterans’ Administration Medical Center, Poplar Bluff, Missouri, USAAbstract: To make clinicians aware of potential sources of error in ophthalmic pharmaceutical clinical trials that can lead to erroneous interpretation of results, a critical review of the study design of various pharmaceutical ophthalmic clinical trials was completed. Discrepancies as a result of study shortcomings may explain observed differences between reported ophthalmic trial data and observed clinical results.Keywords: evidence-based medicine, validity, bias, gold standard