Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats

Ge Song; Wei-Ming Zhang; Yi-Zu Wang; Jia-Bao Guo; Yi-Li Zheng; Zheng Yang; Xuan Su; Yu-Meng Chen; Qing Xie; Xue-Qiang Wang; Xue-Qiang Wang

doi:10.3389/fnmol.2022.865310

Frontiers in Molecular Neuroscience (Mar 2022)

Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats

Ge Song,
Wei-Ming Zhang,
Yi-Zu Wang,
Jia-Bao Guo,
Yi-Li Zheng,
Zheng Yang,
Xuan Su,
Yu-Meng Chen,
Qing Xie,
Xue-Qiang Wang,
Xue-Qiang Wang

Affiliations

Ge Song: Department of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wei-Ming Zhang: Department of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yi-Zu Wang: Department of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Jia-Bao Guo: The Second Clinical Medical School, Xuzhou Medical University, Xuzhou, China
Yi-Li Zheng: Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China
Zheng Yang: Department of Rehabilitation Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Xuan Su: Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China
Yu-Meng Chen: Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China
Qing Xie: Department of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Xue-Qiang Wang: Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China
Xue-Qiang Wang: Department of Rehabilitation Medicine, Shanghai Shangti Orthopaedic Hospital, Shanghai, China

DOI: https://doi.org/10.3389/fnmol.2022.865310
Journal volume & issue: Vol. 15

Abstract

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Exercise can help inhibition of neuropathic pain (NP), but the related mechanism remains being explored. In this research, we performed the effect of swimming exercise on the chronic constriction injury (CCI) rats. Compared with CCI group, the mechanical withdrawal threshold of rats in the CCI-Swim group significantly increased on the 21st and 28th day after CCI surgery. Second-generation RNA-sequencing technology was employed to investigate the transcriptomes of spinal dorsal horns in the Sham, CCI, and CCI-Swim groups. On the 28th day post-operation, 306 intersecting long non-coding RNAs (lncRNAs) and 173 intersecting mRNAs were observed between the CCI vs Sham group and CCI-Swim vs CCI groups. Then, the biological functions of lncRNAs and mRNAs in the spinal dorsal horn of CCI rats were then analyzed. Taking the results together, this study could provide a novel perspective for the treatment for NP.

Published in Frontiers in Molecular Neuroscience

ISSN: 1662-5099 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/molecular-neuroscience

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Abstract

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