Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles

Frederick S. Varn; Erik H. Andrews; David W. Mullins; Chao Cheng

doi:10.1038/ncomms10248

Nature Communications (Jan 2016)

Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles

Frederick S. Varn,
Erik H. Andrews,
David W. Mullins,
Chao Cheng

Affiliations

Frederick S. Varn: Department of Genetics, Geisel School of Medicine at Dartmouth
Erik H. Andrews: Department of Genetics, Geisel School of Medicine at Dartmouth
David W. Mullins: Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth
Chao Cheng: Department of Genetics, Geisel School of Medicine at Dartmouth

DOI: https://doi.org/10.1038/ncomms10248
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

Tumour samples are heterogeneous and are comprised of multiple cell types in addition to cancer cells. Here, the authors devised a method to estimate the relative levels of haematopoietic cells in breast cancer samples and demonstrate that this correlates with prognosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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