Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker

Tiantian Wang; Dean Rao; Chenan Fu; Yiming Luo; Junli Lu; Huifang Liang; Limin Xia; Wenjie Huang

Translational Oncology (Mar 2024)

Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker

Tiantian Wang,
Dean Rao,
Chenan Fu,
Yiming Luo,
Junli Lu,
Huifang Liang,
Limin Xia,
Wenjie Huang

Affiliations

Tiantian Wang: Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China
Dean Rao: Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China
Chenan Fu: Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China
Yiming Luo: Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China
Junli Lu: Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China
Huifang Liang: Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China; Corresponding authors.
Limin Xia: Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Corresponding authors.
Wenjie Huang: Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China; Corresponding author at: Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Journal volume & issue: Vol. 41
p. 101882

Abstract

Read online

ABCC1 belongs to the ATP-binding cassette (ABC) superfamily, which encompasses a total of 48 constituent members. ABCC1 has been shown to be associated with the growth, progression, and drug resistance of various types of cancer. However, the impact of ABCC1 on cancer immune infiltration and pan-cancer prognosis has been rarely studied. Our comprehensive pan-cancer analysis unveiled elevated ABCC1 expression across various cancers. ABCC1 overexpression consistently predicted unfavorable outcomes based on TCGA data. Moreover, ABCC1 expression exhibited intricate associations with diverse immune-related genes and demonstrated a close correlation with immune scores across multiple tumor types. Analysis of scRNA-seq data from the GEO database revealed that the expression of ABCC1 in hepatocellular carcinoma (HCC) cells is significant positively correlated with macrophage infiltration. Furthermore, various in vitro and in vivo experiments substantiated the role of ABCC1 in promoting the progression of HCC, along with increased macrophage recruitment. Based on the results, we propose ABCC1 as a potentially valuable prognostic indicator and a prospective target for immune-based cancer therapies.

Published in Translational Oncology

ISSN: 1944-7124 (Print); 1936-5233 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/translational-oncology/

About the journal

Abstract

Keywords