Metal-Free Photoredox Intramolecular Cyclization of N-Aryl Acrylamides

Abstract

A novel metal-free photoredox-catalyzed cyclization reaction of N-aryl acrylamide is herein reported that provides synthetically valuable oxindole derivatives through the bis-mediation of H2O and aldehyde. In this work, sustainable visible light was used as the energy source, and the organic light-emitting molecule 4CzIPN served as the efficient photocatalyst. The main characteristics of this reaction are environmentally friendly and high yields.

Keywords

• radical cyclization
• hydroarylation
• oxindoles
• visible-light