Prevalence of Infection and Appropriate Antibiotic Treatment in Brain-Dead Organ Donors

Abstract

Purpose: Infection control of the brain-dead donors (BDDs) is crucial to improve graft quality and ensure safety of the recipients. Sparse clinical data about infection of BDD in Korea poses difficulties in choice of antibiotics. We conducted this study to estimate the prevalence of infection and suitability of antibiotic treatment in BDDs. Methods: A retrospective analysis of BDDs between January 2009 and December 2013 was conducted. Types of microbes and prevalence of multi-drug resistant organisms (MDRO) by hospital stay were analyzed. Results: The most common site of infection was the respiratory tract, and seven (12.7%) patients had bacteremia. The overall prevalence of MDRO was 34.5%, although in BDDs with hospital stay more than 16 days that increased to 66.7%. Antibiotic treatment was used at least in days 6~10 of the hospital stay. Conclusion: Infection control of BDDs is essential for transplantation. The development of MDRO and suitability of antibiotics need evaluation.

Keywords

• brain-dead donor
• infection
• multi-drug resistant organism