Nature Communications (Apr 2018)
Towards an arthritis flare-responsive drug delivery system
- Nitin Joshi,
- Jing Yan,
- Seth Levy,
- Sachin Bhagchandani,
- Kai V. Slaughter,
- Nicholas E. Sherman,
- Julian Amirault,
- Yufeng Wang,
- Logan Riegel,
- Xueyin He,
- Tan Shi Rui,
- Michael Valic,
- Praveen K. Vemula,
- Oscar R. Miranda,
- Oren Levy,
- Ellen M. Gravallese,
- Antonios O. Aliprantis,
- Joerg Ermann,
- Jeffrey M. Karp
Affiliations
- Nitin Joshi
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Jing Yan
- Harvard Medical School
- Seth Levy
- Harvard Medical School
- Sachin Bhagchandani
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Kai V. Slaughter
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Nicholas E. Sherman
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Julian Amirault
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Yufeng Wang
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Logan Riegel
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Xueyin He
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Tan Shi Rui
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Michael Valic
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Praveen K. Vemula
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Oscar R. Miranda
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Oren Levy
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- Ellen M. Gravallese
- Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School
- Antonios O. Aliprantis
- Harvard Medical School
- Joerg Ermann
- Harvard Medical School
- Jeffrey M. Karp
- Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital
- DOI
- https://doi.org/10.1038/s41467-018-03691-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
The treatment of inflammatory arthritis by local delivery of therapeutics is limited by short half-lives of drugs. Here the authors demonstrate a hydrogel platform that titrates drug release to arthritis activity.
