Scientific Reports (Jul 2017)

Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs

  • Konstantinos E. Papathanasiou,
  • Petri Turhanen,
  • Stephan I. Brückner,
  • Eike Brunner,
  • Konstantinos D. Demadis

DOI
https://doi.org/10.1038/s41598-017-04956-3
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Abstract Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable.