Prevalence of colistin-resistant Escherichia coli in foods and food-producing animals through the food chain: A worldwide systematic review and meta-analysis
Florencia Aylen Lencina,
Matías Bertona,
María Angeles Stegmayer,
Carolina Raquel Olivero,
Laureano Sebastián Frizzo,
Jorge Alberto Zimmermann,
Marcelo Lisandro Signorini,
Lorena Paola Soto,
María Virginia Zbrun
Affiliations
Florencia Aylen Lencina
Laboratory of Food Analysis, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral, National Council of Scientific and Technical Research (UNL/CONICET), Esperanza, Argentina
Matías Bertona
Department of Public Health, Faculty of Veterinary Science – Litoral National University, Esperanza, Argentina
María Angeles Stegmayer
Laboratory of Food Analysis, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral, National Council of Scientific and Technical Research (UNL/CONICET), Esperanza, Argentina
Carolina Raquel Olivero
Laboratory of Food Analysis, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral, National Council of Scientific and Technical Research (UNL/CONICET), Esperanza, Argentina
Laureano Sebastián Frizzo
Laboratory of Food Analysis, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral, National Council of Scientific and Technical Research (UNL/CONICET), Esperanza, Argentina; Department of Public Health, Faculty of Veterinary Science – Litoral National University, Esperanza, Argentina
Jorge Alberto Zimmermann
Laboratory of Food Analysis, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral, National Council of Scientific and Technical Research (UNL/CONICET), Esperanza, Argentina
Marcelo Lisandro Signorini
Department of Public Health, Faculty of Veterinary Science – Litoral National University, Esperanza, Argentina; Instituto de Investigación de la Cadena Láctea (INTA-CONICET), Estación Experimental Agropecuaria Rafaela, Ruta 34 Km 227, Rafaela, Santa Fe, Argentina; Corresponding author. Ruta 34 Km 227, Rafaela, 300, Santa Fe, Argentina.
Lorena Paola Soto
Laboratory of Food Analysis, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral, National Council of Scientific and Technical Research (UNL/CONICET), Esperanza, Argentina; Department of Public Health, Faculty of Veterinary Science – Litoral National University, Esperanza, Argentina
María Virginia Zbrun
Department of Public Health, Faculty of Veterinary Science – Litoral National University, Esperanza, Argentina; Instituto de Investigación de la Cadena Láctea (INTA-CONICET), Estación Experimental Agropecuaria Rafaela, Ruta 34 Km 227, Rafaela, Santa Fe, Argentina
The purpose of this systematic review and meta-analysis was to summarize the available scientific evidence on the prevalence of colistin-resistant Escherichia coli strains isolated from foods and food-producing animals, the mobile colistin-resistant genes involved, and the impact of the associated variables. A systematic review was carried out in databases according to selection criteria and search strategies established a priori. Random‐effect meta‐analysis models were fitted to estimate the prevalence of colistin-resistant Escherichia coli and to identify the factors associated with the outcome. In general, 4.79% (95% CI: 3.98%–5.76%) of the food and food-producing animal samples harbored colistin-resistant Escherichia coli (total number of colistin-resistant Escherichia coli/total number of samples), while 5.70% (95% confidence interval: 4.97%–6.52%) of the E. coli strains isolated from food and food-producing animal samples harbored colistin resistance (total number of colistin-resistant Escherichia coli/total number of Escherichia coli isolated samples). The prevalence of colistin-resistant Escherichia coli increased over time (P 50%). The prevalence of colistin-resistant Escherichia coli and the mobile colistin resistance-1 gene has a strong impact on the entire food chain. The high prevalence estimated in the retail market represents a potential risk for consumers' health. There is an urgent need to implement based-evidence risk management measures under the “One Health” approach to guarantee public health, food safety, and a sustainable future.
