ИНТЕГРАЛЬНЫЙ ПОДХОД К ОЦЕНКЕ ВЗАИМОСВЯЗИ ИЗМЕНЕНИЙ ПОКАЗАТЕЛЕЙ ИММУННОГО СТАТУСА И МАРКЁРОВ НЕСПЕЦИФИЧЕСКОГО ВОСПАЛЕНИЯ ПРИ ИБС

Abstract

We carried out a comprehensive evaluation of cellular and humoral immunity, nonspecific inflammation markers and their relationship to the thickness of the intima-media of the carotid arteries and the impact of changes in these parameters on the nature of coronary artery disease. The study included 44 patients with chronic forms of coronary artery disease and 35 healthy individuals. In patients with ischemic heart disease has changed mainly of innate immunity, such as the activation of NK-cells (CD16, CD 56), CD 4+CD25+, with regulatory activity in respect of the synthesis of pro- and — inflammatory and anti-inflammatory cytokines, as well as an increase in the level of antiphospholipid antibodies, CRP and the thickness of the complex of intima-media of the carotid arteries, the degree of change in the links of the immunity reflects the severity of the disease.

Keywords

• ischemic artery disease
• cellular immunity
• humoral immunity
• antiphospholipid antibodies
• nonspecific inflammation