Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia

Ming Li; Yuan Gao; Miaowen Jiang; Hongkang Zhang; Yang Zhang; Yan Wu; Wenhao Zhou; Di Wu; Chuanjie Wu; Longfei Wu; Luzi Bao; Xiaoxiao Ge; Zhengfei Qi; Ming Wei; Ang Li; Yuchuan Ding; Jicheng Zhang; Guangzhen Pan; Yu Wu; Yan Cheng; Yufeng Zheng; Xunming Ji

Bioactive Materials (Aug 2023)

Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia

Ming Li,
Yuan Gao,
Miaowen Jiang,
Hongkang Zhang,
Yang Zhang,
Yan Wu,
Wenhao Zhou,
Di Wu,
Chuanjie Wu,
Longfei Wu,
Luzi Bao,
Xiaoxiao Ge,
Zhengfei Qi,
Ming Wei,
Ang Li,
Yuchuan Ding,
Jicheng Zhang,
Guangzhen Pan,
Yu Wu,
Yan Cheng,
Yufeng Zheng,
Xunming Ji

Affiliations

Ming Li: China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
Yuan Gao: School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, 100191, China
Miaowen Jiang: Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China
Hongkang Zhang: School of Materials Science and Engineering, Peking University, Beijing, 100871, China
Yang Zhang: China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
Yan Wu: China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
Wenhao Zhou: Shaanxi Key Laboratory of Biomedical Metallic Materials, Northwest Institute for Nonferrous Metal Research, Xi'an, 710016, China
Di Wu: China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
Chuanjie Wu: China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
Longfei Wu: China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
Luzi Bao: China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
Xiaoxiao Ge: Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China
Zhengfei Qi: Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China
Ming Wei: Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China
Ang Li: Department of Biomedical Engineering, Columbia University, New York City, NY, 10027, USA
Yuchuan Ding: Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, 48201, USA
Jicheng Zhang: Gong Yi Van-research Innovation Composite Material Co. Ltd, Zheng Zhou, 451299, China
Guangzhen Pan: Gong Yi Van-research Innovation Composite Material Co. Ltd, Zheng Zhou, 451299, China
Yu Wu: Gong Yi Van-research Innovation Composite Material Co. Ltd, Zheng Zhou, 451299, China
Yan Cheng: School of Materials Science and Engineering, Peking University, Beijing, 100871, China
Yufeng Zheng: School of Materials Science and Engineering, Peking University, Beijing, 100871, China; Corresponding author.
Xunming Ji: China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, 100191, China; Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Corresponding author. China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Journal volume & issue: Vol. 26
pp. 116 – 127

Abstract

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Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection, but current catheters do not support thermally-insulated transfer of cold infusate, which results in an increased exit temperature, causes hemodilution, and limits its cooling efficiency. Herein, air-sprayed fibroin/silica-based coatings combined with chemical vapor deposited parylene-C capping film was prepared on catheter. This coating features in dual-sized-hollow-microparticle incorporated structures with low thermal conductivity. The infusate exit temperature is tunable by adjusting the coating thickness and infusion rate. No peeling or cracking was observed on the coatings under bending and rotational scenarios in the vascular models. Its efficiency was verified in a swine model, and the outlet temperature of coated catheter (75 μm thickness) was 1.8–2.0 °C lower than that of the uncoated one. This pioneering work on catheter thermal insulation coatings may facilitate the clinical translation of selective endovascular hypothermia for neuroprotection in patients with acute ischemic stroke.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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