GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway

Abstract

Highlights 1. GIMAP7 is upregulated in ovary granulosa cells of PCOS rat; 2. GIMAP7 shRNA relieves the symptoms of PCOS rats; 3. GIMAP7 shRNA inhibits the apoptosis and oxidative stress of KGN cells; 4. GIMAP7 inhibits sonic hedgehog signalling pathway in KGN cells.

Keywords

• Polycystic ovary syndrome
• GIMAP7
• Oxidative stress
• Sonic hedgehog signalling pathway