Frontiers in Chemistry (Dec 2021)

Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch

  • Dan Wu,
  • Zhankui Zhang,
  • Xinyang Yu,
  • Bing Bai,
  • Shaolong Qi

DOI
https://doi.org/10.3389/fchem.2021.817720
Journal volume & issue
Vol. 9

Abstract

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A hydrophilic TPE-based tetracationic cyclophane TPE-cyc was synthesized, which could capture intracellular Nicotinamide adenine dinucleotide phosphate and fuel the antioxidative ability of tumor cells to detoxify reactive oxygen species (ROS). Meanwhile, upon the reduction by cellular GSH, TPE-cyc could light up tumor cells, acting as a GSH-responsive fluorescent switch to image cells with high resolution.

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