Long-term resveratrol supplementation promotes nerve transfer repair in chitin conduit with variated diameters
Bo Ma,
Fengshi Zhang,
Qicheng Li,
Yusong Yuan,
Yuhui Kou
Affiliations
Bo Ma
Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, 100044, China; Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing, 100044, China; National Center for Trauma Medicine, Beijing, 100044, China
Fengshi Zhang
Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, 100044, China; Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing, 100044, China; National Center for Trauma Medicine, Beijing, 100044, China
Qicheng Li
Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, 100044, China; Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing, 100044, China; National Center for Trauma Medicine, Beijing, 100044, China
Yusong Yuan
Department of Orthopedics, China-Japan Friendship Hospital, Beijing, China; Corresponding author.
Yuhui Kou
Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, 100044, China; Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing, 100044, China; National Center for Trauma Medicine, Beijing, 100044, China; Corresponding author. Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, 100044, China.
Background: Peripheral Nerve Injury often cause severe functional impairments and long-term disability. There are various surgical methods to treat PNI, however they all have different shortcomings such as limited donor nerve choices and mismatch of nerve diameters. In addition, effective nerve function recovery also requires continuous nutritional support. Our study focused on the outcome of long-term resveratrol (RSV) supplementation in combination with small gap chitin conduits with variated diameters to promote nerve transfer repair. Methods: We constructed SD rat nerve transfer model with small gap conduit for tibial nerve repair. Then the rats were divided into saline, RSV, mecobalamin, and sham group, which receives different gavage treatments respectively. 16 weeks after surgery, the functional recovery of the tibial nerve was assessed in each group of rats. Results: Compared to the saline group, the RSV group and mecobalamin group showed enhanced performance in both motor function and nerve conduction, as well as improved histomorphology of both nerve and muscle fibers. Conclusion: Long-term RSV supplementation significantly improved functional recovery of tibial nerve after nerve transfer in small gap conduit with variated diameters.
